['NC1[C@H]2COC[C@@H]12', 'Cc1ccc(F)c([SH](=O)=O)c1', 'C1OC[C@H]2C[C@@H]12', 'Cc1ccc(F)c(S(N)(=O)=O)c1']
The Murcko scaffold (minmal number of connected rings) of <smiles></smiles> is O=S(=O)(NC1[C@H]2COC[C@@H]12)c1ccccc1.