['C[C@H]1CO1', 'Oc1ccc(C(F)(F)F)cc1', 'OC[C@H]1CO1', 'FC(F)(F)c1ccccc1', 'C1CO1', 'COc1ccc(C(F)(F)F)cc1', 'FC(F)F', 'c1ccc(OC[C@H]2CO2)cc1']
The Murcko scaffold (minmal number of connected rings) of <smiles></smiles> is c1ccc(OC[C@H]2CO2)cc1.