['C[C@H]1OCC[C@H]1N', 'O=[SH](=O)c1cc(Cl)sc1Cl', 'C[C@@H]1CCCO1', 'NS(=O)(=O)c1cc(Cl)sc1Cl']
The Murcko scaffold (minmal number of connected rings) of <smiles></smiles> is O=S(=O)(N[C@@H]1CCOC1)c1ccsc1.