decrease therapeutic efficacy
prompt:molecule-molecule interaction [SEP] smiles:NC1=NC(N)=C(N=N1)C1=C(Cl)C(Cl)=CC=C1.[H][C@@](N1CCC2=C(C1)C=CS2)(C(=O)OC)C1=CC=CC=C1Cl
wspaced:decrease therapeutic efficacy