decrease therapeutic efficacy
prompt:molecule-molecule interaction [SEP] smiles:COC1=C(OC)C(CS(=O)C2=NC3=C(N2)C=C(OC(F)F)C=C3)=NC=C1.[H][C@@](N1CCC2=C(C1)C=CS2)(C(=O)OC)C1=CC=CC=C1Cl
wspaced:decrease therapeutic efficacy