decrease therapeutic efficacy
prompt:molecule-molecule interaction [SEP] smiles:COC1=C(C\C=C(/C)CCC(O)=O)C(O)=C2C(=O)OCC2=C1C.CC1CC2=CC=CC=C2N1NC(=O)C1=CC(=C(Cl)C=C1)S(N)(=O)=O
wspaced:decrease therapeutic efficacy