decrease therapeutic efficacy
prompt:molecule-molecule interaction [SEP] smiles:COC1=C(OCCCN2CCC(CC2)C2=NOC3=C2C=CC(F)=C3)C=CC(=C1)C(C)=O.CN1C(=O)C=C(N2CCC[C@@H](N)C2)N(CC2=C(C=CC=C2)C#N)C1=O
wspaced:decrease therapeutic efficacy