decrease therapeutic efficacy
prompt:molecule-molecule interaction [SEP] smiles:[Ca++].[Ca++].[Ca++].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.COC1=CC=C(\C=C\C(=O)NC2=CC=CC=C2C(O)=O)C=C1OC
wspaced:decrease therapeutic efficacy