decrease therapeutic efficacy
prompt:molecule-molecule interaction [SEP] smiles:COC1=CC=C(C=C1)[C@@H]1SC2=C(C=CC=C2)N(CCN(C)C)C(=O)[C@@H]1OC(C)=O.[H][C@@](N1CCC2=C(C1)C=CS2)(C(=O)OC)C1=CC=CC=C1Cl
wspaced:decrease therapeutic efficacy