decrease therapeutic efficacy
prompt:molecule-molecule interaction [SEP] smiles:COC1=CC2=C(C=C1)N(C(=O)C1=CC=C(Cl)C=C1)C(C)=C2CC(=O)OCC(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO
wspaced:decrease therapeutic efficacy