decrease therapeutic efficacy
prompt:molecule-molecule interaction [SEP] smiles:C\C(O)=C(/C#N)C(=O)NC1=CC=C(C=C1)C(F)(F)F.NS(=O)(=O)C1=C(Cl)C=CC(=C1)C1(O)NC(=O)C2=CC=CC=C12
wspaced:decrease therapeutic efficacy