decrease therapeutic efficacy
prompt:molecule-molecule interaction [SEP] smiles:CO\N=C1/CN(CC1CN)C1=NC2=C(C=C1F)C(=O)C(=CN2C1CC1)C(O)=O.OS(=O)(=O)OC1=CC=C(C=C1)C(C1=CC=C(OS(O)(=O)=O)C=C1)C1=CC=CC=N1
wspaced:decrease therapeutic efficacy