decrease therapeutic efficacy
prompt:molecule-molecule interaction [SEP] smiles:CNC1=NC=C(C=C1C)C1=CC=C2C(=O)C(=CN(C3CC3)C2=C1C)C(O)=O.OS(=O)(=O)OC1=CC=C(C=C1)C(C1=CC=C(OS(O)(=O)=O)C=C1)C1=CC=CC=N1
wspaced:decrease therapeutic efficacy