decrease therapeutic efficacy
prompt:molecule-molecule interaction [SEP] smiles:CCCC(C)C1(CC)C(=O)NC(=O)NC1=O.[H][C@@]12CC[C@@](OC(C)=O)(C#C)[C@@]1(C)CC[C@]1([H])[C@@]3([H])CC[C@H](OC(C)=O)C=C3CC[C@@]21[H]
wspaced:decrease therapeutic efficacy