decrease therapeutic efficacy
prompt:molecule-molecule interaction [SEP] smiles:NCCN.CN1C2=C(NC=N2)C(=O)N(C)C1=O.CN1C2=C(NC=N2)C(=O)N(C)C1=O.CCOC(=O)C1=C2CN(C)C(=O)C3=C(C=CC(F)=C3)N2C=N1
wspaced:decrease therapeutic efficacy