decrease therapeutic efficacy
prompt:molecule-molecule interaction [SEP] smiles:COC1=CC2=C(C=C1)C=C(CCC(C)=O)C=C2.NS(=O)(=O)C1=C(Cl)C=CC(=C1)C1(O)NC(=O)C2=CC=CC=C12
wspaced:decrease therapeutic efficacy