decrease therapeutic efficacy
prompt:molecule-molecule interaction [SEP] smiles:COCCCOC1=C(C)C(CS(=O)C2=NC3=CC=CC=C3N2)=NC=C1.CCCCCCOC(=O)\N=C(\N)C1=CC=C(NCC2=NC3=C(C=CC(=C3)C(=O)N(CCC(=O)OCC)C3=NC=CC=C3)N2C)C=C1
wspaced:decrease therapeutic efficacy