decrease therapeutic efficacy
prompt:molecule-molecule interaction [SEP] smiles:COC1=C(C\C=C(/C)CCC(O)=O)C(O)=C2C(=O)OCC2=C1C.CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O
wspaced:decrease therapeutic efficacy