decrease therapeutic efficacy
prompt:molecule-molecule interaction [SEP] smiles:C[C@@H](OC[C@]1(CC[C@]2(CCC(=O)N2)CN1)C1=CC=CC=C1)C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F.COC1=CC=CC(=C1)[C@@]1(O)CCCC[C@@H]1CN(C)C
wspaced:decrease therapeutic efficacy