decrease therapeutic efficacy
prompt:molecule-molecule interaction [SEP] smiles:CN1C2=C(C3=CC=CC=C13)C(=O)C(CN1C=CN=C1C)CC2.[H][C@]12C[C@@H](CN(CCC)[C@]1([H])CC1=CC=CC(O)=C1C2)NS(=O)(=O)N(CC)CC
wspaced:decrease therapeutic efficacy