decrease therapeutic efficacy
prompt:molecule-molecule interaction [SEP] smiles:COC1=CC2=C(C=C1)C=C(CCC(C)=O)C=C2.CC1NC2=CC(Cl)=C(C=C2C(=O)N1C1=CC=CC=C1C)S(N)(=O)=O
wspaced:decrease therapeutic efficacy