decrease therapeutic efficacy
prompt:molecule-molecule interaction [SEP] smiles:COC1=C(OC)C=C2C(=O)C(CC3CCN(CC4=CC=CC=C4)CC3)CC2=C1.O=C1N(CC2=CC=CC=C2)C2C[S+]3CCCC3C2N1CC1=CC=CC=C1
wspaced:decrease therapeutic efficacy