decrease therapeutic efficacy
prompt:molecule-molecule interaction [SEP] smiles:[Cl-].[Cl-].[Ca++].COC(=O)C1=C(C)NC(C)=C(C1C1=CC(=CC=C1)[N+]([O-])=O)C(=O)OC(C)(C)CN(C)CCC(C1=CC=CC=C1)C1=CC=CC=C1
wspaced:decrease therapeutic efficacy