decrease therapeutic efficacy
prompt:molecule-molecule interaction [SEP] smiles:CN1C(C(=O)NC2=CC=CC=N2)=C(O)C2=C(C=CS2)S1(=O)=O.CC1CC2=CC=CC=C2N1NC(=O)C1=CC(=C(Cl)C=C1)S(N)(=O)=O
wspaced:decrease therapeutic efficacy