decrease therapeutic efficacy
prompt:molecule-molecule interaction [SEP] smiles:NC(=N)NC1=CC=C(C=C1)C(=O)OC1=CC2=C(C=C1)C=C(C=C2)C(N)=N.NS(=O)(=O)C1=C(Cl)C=C2NCNS(=O)(=O)C2=C1
wspaced:decrease therapeutic efficacy