decrease therapeutic efficacy
prompt:molecule-molecule interaction [SEP] smiles:NCCN.CN1C2=C(NC=N2)C(=O)N(C)C1=O.CN1C2=C(NC=N2)C(=O)N(C)C1=O.CN(C)C(=O)OC1N=C(C2=CC=CC=C2)C2=C(C=CC(Cl)=C2)N(C)C1=O
wspaced:decrease therapeutic efficacy