decrease therapeutic efficacy
prompt:molecule-molecule interaction [SEP] smiles:[Ca++].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)C([O-])=O.NC1=NC(N)=C(N=N1)C1=C(Cl)C(Cl)=CC=C1
wspaced:decrease therapeutic efficacy