decrease therapeutic efficacy
prompt:molecule-molecule interaction [SEP] smiles:COC1=CC2=C(C=C1)N(C(=O)C1=CC=C(Cl)C=C1)C(C)=C2CC(=O)OCC(O)=O.CC(C)(N)CO.CN1C2=C(NC(Br)=N2)C(=O)N(C)C1=O
wspaced:decrease therapeutic efficacy