decrease therapeutic efficacy
prompt:molecule-molecule interaction [SEP] smiles:[Ca++].[Ca++].[Ca++].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.NC1=NC(N)=C(N=N1)C1=C(Cl)C(Cl)=CC=C1
wspaced:decrease therapeutic efficacy