decrease therapeutic efficacy
prompt:molecule-molecule interaction [SEP] smiles:COC1=CC2=C(C=C1)N=C(N2)S(=O)CC1=NC=C(C)C(OC)=C1C.OC(CC1=CN=CC=C1)(P(O)(O)=O)P(O)(O)=O
wspaced:decrease therapeutic efficacy