decrease therapeutic efficacy
prompt:molecule-molecule interaction [SEP] smiles:COC1=C(O)C=CC(CNC(=O)CCCC\C=C/C(C)C)=C1.[H][C@@](N1CCC2=C(C1)C=CS2)(C(=O)OC)C1=CC=CC=C1Cl
wspaced:decrease therapeutic efficacy