decrease therapeutic efficacy
prompt:molecule-molecule interaction [SEP] smiles:ClC1=C(CCN2CCN(CC2)C2=NSC3=CC=CC=C23)C=C2CC(=O)NC2=C1.OC12CC3CC(C1)CC(C3)(C2)NCC(=O)N1CCC[C@H]1C#N
wspaced:decrease therapeutic efficacy