decrease therapeutic efficacy
prompt:molecule-molecule interaction [SEP] smiles:CN(CC1=CN=C2N=C(N)N=C(N)C2=N1)C1=CC=C(C=C1)C(=O)N[C@@H](CCC(O)=O)C(O)=O.NS(=O)(=O)C1=C(Cl)C=C(NCC2=CC=CO2)C(=C1)C(O)=O
wspaced:decrease therapeutic efficacy