decrease therapeutic efficacy
prompt:molecule-molecule interaction [SEP] smiles:[H][C@@]12C[C@]1([H])[C@@]1([H])[C@]3([H])[C@]4([H])C[C@]4([H])[C@@]4(CCC(=O)O4)[C@@]3(C)CC[C@]1([H])[C@@]1(C)CCC(=O)C=C21.OC12CC3CC(C1)CC(C3)(C2)NCC(=O)N1CCC[C@H]1C#N
wspaced:decrease therapeutic efficacy