decrease therapeutic efficacy
prompt:molecule-molecule interaction [SEP] smiles:CC1CC2=CC=CC=C2N1NC(=O)C1=CC(=C(Cl)C=C1)S(N)(=O)=O.CN(CCOC1=CC=C(CC2SC(=O)NC2=O)C=C1)C1=CC=CC=N1
wspaced:decrease therapeutic efficacy