decrease therapeutic efficacy
prompt:molecule-molecule interaction [SEP] smiles:COC1=CC2=C(C=C1)C=C(CCC(C)=O)C=C2.OCC([NH3+])(CO)CO.CCCCC[C@@](O)(C)\C=C\[C@H]1[C@@H](O)C[C@H](O)[C@@H]1C\C=C/CCCC(=O)[O-]
wspaced:decrease therapeutic efficacy