decrease therapeutic efficacy
prompt:molecule-molecule interaction [SEP] smiles:COC1=C(OC)C=C2C(=O)C(CC3CCN(CC4=CC=CC=C4)CC3)CC2=C1.CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)C(CO)C1=CC=CC=C1
wspaced:decrease therapeutic efficacy