decrease therapeutic efficacy
prompt:molecule-molecule interaction [SEP] smiles:CN1C(CCl)NC2=CC(Cl)=C(C=C2S1(=O)=O)S(N)(=O)=O.CN(CCOC1=CC=C(CC2SC(=O)NC2=O)C=C1)C1=CC=CC=N1
wspaced:decrease therapeutic efficacy