decrease therapeutic efficacy
prompt:molecule-molecule interaction [SEP] smiles:CN1C(C(=O)NC2=NC=CC=C2)=C(O)C2=C(C=CC=C2)S1(=O)=O.CN1C(CCl)NC2=CC(Cl)=C(C=C2S1(=O)=O)S(N)(=O)=O
wspaced:decrease therapeutic efficacy