decrease therapeutic efficacy
prompt:molecule-molecule interaction [SEP] smiles:NC(=N)NC1=CC=C(C=C1)C(=O)OC1=CC2=C(C=C1)C=C(C=C2)C(N)=N.CCC1NC(=O)C2=CC(=C(Cl)C=C2N1)S(N)(=O)=O
wspaced:decrease therapeutic efficacy