decrease therapeutic efficacy
prompt:molecule-molecule interaction [SEP] smiles:COC1=C(C=C(C=C1)C1=CC2=C(C=C1)C=C(C=C2)C(O)=O)C12CC3CC(CC(C3)C1)C2.[H]\C(C)=C(/C(=C(\[H])C)/C1=CC=C(O)C=C1)\C1=CC=C(O)C=C1
wspaced:decrease therapeutic efficacy