decrease therapeutic efficacy
prompt:molecule-molecule interaction [SEP] smiles:[Ca++].CC(O)C([O-])=O.CC(O)C([O-])=O.CC(C)OC(=O)C1=C(C)NC(N)=C(C1C1=CC=CC(=C1)[N+]([O-])=O)C(=O)OC1CN(C1)C(C1=CC=CC=C1)C1=CC=CC=C1
wspaced:decrease therapeutic efficacy