decrease therapeutic efficacy
prompt:molecule-molecule interaction [SEP] smiles:CC12CC3CC(C)(C1)CC(N)(C3)C2.NC(=O)C([C@@H]1CCN(CCC2=CC3=C(OCC3)C=C2)C1)(C1=CC=CC=C1)C1=CC=CC=C1
wspaced:decrease therapeutic efficacy