decrease therapeutic efficacy
prompt:molecule-molecule interaction [SEP] smiles:[Ca++].[Ca++].[Ca++].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.COC1=C(OC)C=C(C[N+]2(CCOCCC3CCC4CC3C4(C)C)CCOCC2)C(Br)=C1
wspaced:decrease therapeutic efficacy