decrease therapeutic efficacy
prompt:molecule-molecule interaction [SEP] smiles:COC1=C(C=C(C=C1)C1=CC2=C(C=C1)C=C(C=C2)C(O)=O)C12CC3CC(CC(C3)C1)C2.CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(O)=O
wspaced:decrease therapeutic efficacy