decrease therapeutic efficacy
prompt:molecule-molecule interaction [SEP] smiles:CN1C2=C(N(CC(O)CO)C=N2)C(=O)N(C)C1=O.CC1=NC=C2CN=C(C3=CC=CC=C3F)C3=C(C=CC(Cl)=C3)N12
wspaced:decrease therapeutic efficacy