decrease therapeutic efficacy
prompt:molecule-molecule interaction [SEP] smiles:COC1=CC=C(\C=C\C(=O)NC2=CC=CC=C2C(O)=O)C=C1OC.CC1CC2=CC=CC=C2N1NC(=O)C1=CC(=C(Cl)C=C1)S(N)(=O)=O
wspaced:decrease therapeutic efficacy