decrease therapeutic efficacy
prompt:molecule-molecule interaction [SEP] smiles:CC(=O)[C@@]1(O)CC[C@H]2[C@@H]3C=C(C)C4=CC(=O)CC[C@@H]4[C@H]3CC[C@]12C.NC(=N)NC1=CC=C(C=C1)C(=O)OC1=CC2=C(C=C1)C=C(C=C2)C(N)=N
wspaced:decrease therapeutic efficacy