decrease therapeutic efficacy
prompt:molecule-molecule interaction [SEP] smiles:COC1=C(C\C=C(/C)CCC(=O)OCCN2CCOCC2)C(O)=C2C(=O)OCC2=C1C.CCNC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1\C=C\[C@@H](O)CCC1=CC=CC=C1
wspaced:decrease therapeutic efficacy