decrease therapeutic efficacy
prompt:molecule-molecule interaction [SEP] smiles:CC[N+](CC)(CCNC(=O)C(=O)NCC[N+](CC)(CC)CC1=CC=CC=C1Cl)CC1=CC=CC=C1Cl.O=C1N(CC2=CC=CC=C2)C2C[S+]3CCCC3C2N1CC1=CC=CC=C1
wspaced:decrease therapeutic efficacy