decrease therapeutic efficacy
prompt:molecule-molecule interaction [SEP] smiles:COC1=CC(C)=NN1C1=NC(C)=CC(OC)=N1.CN1C(CSCC(F)(F)F)NC2=CC(Cl)=C(C=C2S1(=O)=O)S(N)(=O)=O
wspaced:decrease therapeutic efficacy