decrease therapeutic efficacy
prompt:molecule-molecule interaction [SEP] smiles:COC1=C(C=C(C=C1)C1=CC2=C(C=C1)C=C(C=C2)C(O)=O)C12CC3CC(CC(C3)C1)C2.CCC12CCC3C(CCC4=CC(=O)CCC34)C1CCC2(O)C#C
wspaced:decrease therapeutic efficacy