decrease therapeutic efficacy
prompt:molecule-molecule interaction [SEP] smiles:COC1=CC=C(\C=C\C(=O)NC2=CC=CC=C2C(O)=O)C=C1OC.[H][C@@](N1CCC2=C(C1)C=CS2)(C(=O)OC)C1=CC=CC=C1Cl
wspaced:decrease therapeutic efficacy