decrease therapeutic efficacy
prompt:molecule-molecule interaction [SEP] smiles:COC1=CC=CC=C1OCC(O)CN1CCN(CC(=O)NC2=C(C)C=CC=C2C)CC1.[H][C@]12C=C[C@H](O)[C@@H]3OC4=C5C(C[C@H]1N(C)CC[C@@]235)=CC=C4OC
wspaced:decrease therapeutic efficacy