decrease therapeutic efficacy
prompt:molecule-molecule interaction [SEP] smiles:COC1=C(C=C(C=C1)C1=CC2=C(C=C1)C=C(C=C2)C(O)=O)C12CC3CC(CC(C3)C1)C2.CCC1NC(=O)C2=CC(=C(Cl)C=C2N1)S(N)(=O)=O
wspaced:decrease therapeutic efficacy