decrease therapeutic efficacy
prompt:molecule-molecule interaction [SEP] smiles:COC1=CC=C(\C=C\C(=O)NC2=CC=CC=C2C(O)=O)C=C1OC.CCNC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1\C=C\[C@@H](O)CCC1=CC=CC=C1
wspaced:decrease therapeutic efficacy