decrease therapeutic efficacy
prompt:molecule-molecule interaction [SEP] smiles:COC1=CC2=C(SC3=C(C=CC=C3)N2C[C@H](C)CN(C)C)C=C1.[H][C@]12C[C@@H](CN(CCC)[C@]1([H])CC1=CC=CC(O)=C1C2)NS(=O)(=O)N(CC)CC
wspaced:decrease therapeutic efficacy