decrease therapeutic efficacy
prompt:molecule-molecule interaction [SEP] smiles:CC1=CC=C(NC2=C(Cl)C=CC=C2F)C(CC(O)=O)=C1.[H][C@]12C[C@@H](O)[C@H](\C=C\[C@@H](O)C(C)CC#CC)[C@@]1([H])C\C(C2)=C\CCCC(O)=O
wspaced:decrease therapeutic efficacy