decrease therapeutic efficacy
prompt:molecule-molecule interaction [SEP] smiles:C\C(O)=C(/C#N)C(=O)NC1=CC=C(C=C1)C(F)(F)F.CC1NC2=CC(Cl)=C(C=C2C(=O)N1C1=CC=CC=C1C)S(N)(=O)=O
wspaced:decrease therapeutic efficacy