decrease therapeutic efficacy
prompt:molecule-molecule interaction [SEP] smiles:COC1=C(OCCCN2CCC(CC2)C2=NOC3=C2C=CC(F)=C3)C=CC(=C1)C(C)=O.[H][C@@]12C[C@]1([H])N([C@@H](C2)C#N)C(=O)[C@@H](N)C12CC3CC(CC(O)(C3)C1)C2
wspaced:decrease therapeutic efficacy