decrease therapeutic efficacy
prompt:molecule-molecule interaction [SEP] smiles:CC1CC2=CC=CC=C2N1NC(=O)C1=CC(=C(Cl)C=C1)S(N)(=O)=O.CC#CCN1C(=NC2=C1C(=O)N(CC1=NC3=C(C=CC=C3)C(C)=N1)C(=O)N2C)N1CCC[C@@H](N)C1
wspaced:decrease therapeutic efficacy