decrease therapeutic efficacy
prompt:molecule-molecule interaction [SEP] smiles:COC1=C(OCCCN2CCC(CC2)C2=NOC3=C2C=CC(F)=C3)C=CC(=C1)C(C)=O.OC12CC3CC(C1)CC(C3)(C2)NCC(=O)N1CCC[C@H]1C#N
wspaced:decrease therapeutic efficacy