decrease therapeutic efficacy
prompt:molecule-molecule interaction [SEP] smiles:COC1=CC2=C(NC(=N2)[S@@](=O)CC2=NC=C(C)C(OC)=C2C)C=C1.OC(CN1C=CN=C1)(P(O)(O)=O)P(O)(O)=O
wspaced:decrease therapeutic efficacy